Author

Devlin Frost

Boston Children's HospitalORCID 0000-0002-2198-5529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Clifford J. WoolfiD· 3 shared Xuan HuangiD· 3 shared Bruno BoiviniD· 2 shared Kevin C. EgganiD· 2 shared Kuchuan CheniD· 2 shared Laura Perrault· 2 shared Ole Wiskow· 2 shared Riki KawaguchiiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Clifford J. WoolfORCID

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3 papers

Recent·Most cited

NEK1 modulates neurite outgrowth in motor neurons through coordinating retromer formation

Xuan Huang, Juan A. Osés-Prieto, Riki Kawaguchi, Laura Perrault, Devlin Frost, Kuchuan Chen, Feng Guo, Bingjie Zhang, Pinghan Zhao, Tammy Szu‐Yu Ho, Roshan Pandey, Daniel H. Geschwind, Alma L. Burlingame, Clifford J. Woolf

This study identifies NEK1's role in motor neuron neurite outgrowth by coordinating retromer formation through interactions with SMC3.

bioRxiv · May 6, 2024 · PreprintNeuroscience

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

Xuan Huang, Seungkyu Lee, Riki Kawaguchi, Ole Wiskow, Sulagna Dia Ghosh, Devlin Frost, Laura Perrault, Roshan Pandey, Kuchuan Chen, Joseph R. Klim, Bruno Boivin, Crystal Hermawan, Kenneth J. Livak, Dan H. Geschwind, Brian J. Wainger, , Clifford J. Woolf

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

bioRxiv · May 7, 2023 · PreprintNeuroscience

A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening

Bruno Boivin, Kasper C. D. Roet, Xuan Huang, Kyle W. Karhohs, Mohammad Hossein Rohban, Jackson Sandoe, Ole Wiskow, Rie K. Maeda, Alyssa Grantham, Mary Kate Dornon, Jenny Shao, Devlin Frost, Dylan S. Baker, Kevin C. Eggan, Anne Elizabeth Carpenter, Clifford J. Woolf

The paper introduces a cloud-based platform for analyzing calcium activity in motor neurons to identify compounds that reverse disease phenotypes in amyotrophic lateral sclerosis.

Molecular Biology of the Cell · Dec 15, 2021Peer-reviewedNeuroscience