Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability
Xuan Huang, Seungkyu Lee, Riki Kawaguchi, Ole Wiskow, Sulagna Dia Ghosh, Devlin Frost, Laura Perrault, Roshan Pandey, Kuchuan Chen, Joseph R. Klim, Bruno Boivin, Crystal Hermawan, Kenneth J. Livak, Dan H. Geschwind, Brian J. Wainger, , Clifford J. Woolf
The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.
bioRxiv · May 7, 2023 · PreprintNeuroscience