Author

Derek F. Harris

Utah State UniversityORCID 0000-0003-4277-2976Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Betül KaçariD· 2 shared Holly R. RuckeriD· 2 shared Lance C. SeefeldtiD· 2 shared Amanda K. GarciaiD· 1 shared Hannah FeinsilberiD· 1 shared Kunmanee BubphamaneeiD· 1 shared Kurt O. KonhauseriD· 1 shared Roger BuickiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersEvolutionary Biology

Betül KaçarORCID

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2 papers

Recent·Most cited

Evolutionary BiologyNature CommunicationsPeer-reviewedJan 22, 2026

Resurrected nitrogenases recapitulate canonical N-isotope biosignatures over two billion years

Holly R. Rucker, Kunmanee Bubphamanee, Derek F. Harris…·Betül Kaçar

The paper resurrects ancient nitrogenase enzymes and shows their nitrogen isotope signatures are similar to modern ones, suggesting evolutionary invariance and supporting the use of N-isotope biosignatures for detecting life.

1 citation

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Evolutionary BiologymBioPeer-reviewedJun 13, 2024

The Origins of ATP Dependence in Biological Nitrogen Fixation

Derek F. Harris, Holly R. Rucker, Amanda K. Garcia…·Lance C. Seefeldt

This study experimentally reconstructs an ancestral nitrogenase enzyme and shows it strictly requires ATP hydrolysis for N2 reduction, decoupling cofactor selection from environmental availability.

22 citations

experimental assay

𝕏 PostBluesky