PhysiologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewed
Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes
Varsha Singh, Ruxian Lin, Laxmi Sunuwar…·Rafiquel I. Sarker
This study identifies distinct mechanisms of NHE3 regulation in type 1 and type 2 diabetes, showing SNX17 loss in T1D reduces NHE3 stability while T2D involves transcriptional downregulation in the colon.
DOI 10.1152/ajpcell.00590.2025