Author

Mark Donowitz

Johns Hopkins UniversityORCID 0000-0003-0477-8824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

Ruxian Lin· 2 shared Varsha SinghiD· 2 shared Alaullah SheikhiD· 1 shared Bernhard B. SingeriD· 1 shared Bipul SetuiD· 1 shared Chung‐Ming TseiD· 1 shared Clayton D. Harro· 1 shared Dario BoffelliiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

Ruxian Lin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewedSep 10, 2025

Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes

Varsha Singh, Ruxian Lin, Laxmi Sunuwar…·Rafiquel I. Sarker

This study identifies distinct mechanisms of NHE3 regulation in type 1 and type 2 diabetes, showing SNX17 loss in T1D reduces NHE3 stability while T2D involves transcriptional downregulation in the colon.

DOI 10.1152/ajpcell.00590.2025

mouseproteomics

𝕏 PostBluesky

PhysiologyiSciencePeer-reviewedApr 17, 2025

Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.

Rong Yan, Zixin Zhang, Hugo R. de Jonge…·Varsha Singh

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedSep 12, 2024

Host-derived CEACAM-laden vesicles engage enterotoxigenic E. coli for elimination and toxin neutralization.

Alaullah Sheikh, Debayan Ganguli, Tim J. Vickers…·James M. Fleckenstein

The paper shows that host-derived CEACAM-laden vesicles capture ETEC and its toxins, reducing pathogen load and neutralizing toxins during infection.

5 citations

humanproteomics

𝕏 PostBluesky