Author

Varsha Singh

Johns Hopkins UniversityORCID 0000-0003-0796-2619Unclaimed ORCID profile · follow to get notified of new preprints

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Varsha Singh3 papers

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Mark DonowitziD· 2 shared Ruxian Lin· 2 shared Chung‐Ming TseiD· 1 shared Dario BoffelliiD· 1 shared Hugo R. de JongeiD· 1 shared Huimin YuiD· 1 shared Jianbo YangiD· 1 shared Laxmi SunuwariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

Mark DonowitzORCID

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2 papers

Recent·Most cited

PhysiologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewedSep 10, 2025

Differential Regulation of NHE3 Expression in Type 1 and Type 2 Diabetic Intestine: Impaired Endosomal Regulation of NHE3 Expression in Type 1 Diabetes

Varsha Singh, Ruxian Lin, Laxmi Sunuwar…·Rafiquel I. Sarker

This study identifies distinct mechanisms of NHE3 regulation in type 1 and type 2 diabetes, showing SNX17 loss in T1D reduces NHE3 stability while T2D involves transcriptional downregulation in the colon.

DOI 10.1152/ajpcell.00590.2025

mouseproteomics

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PhysiologyiSciencePeer-reviewedApr 17, 2025

Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids 1 secrete fluid in response to forskolin and linaclotide.

Rong Yan, Zixin Zhang, Hugo R. de Jonge…·Varsha Singh

The paper shows partially differentiated CFTR-mutant enteroids secrete fluid in response to forskolin and linaclotide, with reduced efficacy compared to healthy enteroids.

3 citations

humanbulk RNA-seq

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