Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammation
Teresa Neuwirth, Daniel Malzl, Katja Knapp, Panagiota Tsokkou, Lisa Kleißl, Anna Gabriel, Baerbel Reininger, Christian Freystätter, Nara Marella, Ana P. Kutschat, Elisabeth Ponweiser, Arvand Haschemi, Davide Seruggia, Jörg Menche, Erwin Friedrich Wagner, Georg Stary
The paper identifies SAT1 as a marker of skin-specific Treg dysfunction in TH17-mediated inflammation and shows targeting SSAT can rescue Treg function in a mouse model.
Immunity · Feb 28, 2025Peer-reviewedImmunology