Davide Seruggia

Induced Estrogen Receptor SUMOylation drives SERD activity

This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.

Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression

This study identifies ARID5B as a chromatin repressor that interacts with HDAC1/2 to repress B cell-specific genes, linking its germline variants to B-ALL risk.

Disruption of the SAGA CORE triggers collateral degradation of KAT2A

The paper identifies SAGA CORE subunits as essential for KAT2A stability, showing that their disruption leads to proteasomal degradation of KAT2A and reduced H3K9 acetylation.

Directing stem cell differentiation by chromatin state approximation

The paper uses chromatin state approximation to optimize stem cell differentiation protocols, finding that greedy selection based on ATAC-seq profiles improves erythroblast generation.

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammation

The paper identifies SAT1 as a marker of skin-specific Treg dysfunction in TH17-mediated inflammation and shows targeting SSAT can rescue Treg function in a mouse model.

Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6

This study investigates the DNA-binding mechanism of BCL11A, revealing the role of ZnF6 in repression of {gamma}-globin gene expression and its implications for therapeutic design.

CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing

CRISPR-CLEAR maps regulatory elements at nucleotide resolution by directly assessing genotype-phenotype effects through targeted sequencing of CRISPR-introduced alleles.

A slc38a8 mouse model of FHONDA syndrome faithfully recapitulates the visual deficits of albinism without pigmentation defects

The paper generates a mouse model of FHONDA syndrome with mutations in SLC38A8, showing normal pigmentation but visual deficits similar to albinism.

Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression

The paper identifies boundary sequences at the mouse tyrosinase locus that act as enhancers and insulators, preventing cross-talk with adjacent genes.

Enhancer-dependence of gene expression increases with developmental age

The paper shows that enhancer-dependence of gene expression increases with developmental age in mouse and human cells.