Daniel Malzl

This study shows that LAP2 depletion in fibroblasts causes chromatin reorganization, A-type lamin binding to open regions, and changes in gene expression and chromatin remodeler distribution.

reComBat-seq removes batch effects in transcriptomics data while preserving count data structure and compatibility with downstream analyses.

This study shows that tRNA thiolation defects in humans cause proteostasis and tissue homeostasis issues, but mice with similar defects develop normally.

The paper shows that specific DNA replication origins are still used and excess MCM2-7 is loaded in ORC-deficient human cancer cells.

The paper identifies SAT1 as a marker of skin-specific Treg dysfunction in TH17-mediated inflammation and shows targeting SSAT can rescue Treg function in a mouse model.

This study identifies AMAN-3 as a Golgi α-mannosidase essential for tri-fucosylation of nematode N-glycans, which affects growth and behavior in C. elegans.

CellWhisperer enables chat-based exploration of single-cell RNA-seq data using natural language by connecting transcriptomes with text through multimodal learning.

This study shows RIF1 regulates early replication timing and origin activity in B cells by interacting with MCM proteins, influencing gene replication without major effects on gene expression or genome organization.

The paper investigates how changes in large neutral amino acid metabolism during development affect neuronal excitability and survival, finding that Slc7a5 deletion disrupts lipid metabolism and leads to long-term circuit dysfunction.

The paper shows that a de novo TAD boundary formed by transcriptional activity at acceptor S regions facilitates synapsis during antibody class switch recombination.

This study shows DNA replication timing regulates oncogenic chromosomal translocations by affecting DSB ligation, independent of DSB frequency.