Author

Xiaojia Tang

Mayo ClinicORCID 0000-0002-1990-7783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Organism:mouse· 1

Frequent Co-Authors

Karunya K. KandimallaiD· 3 shared Krishna R. KalariiD· 3 shared Vrishali S. SalianiD· 2 shared Geoffry L. Curran· 1 shared Purna KashyapiD· 1 shared Suresh Kumar Swaminathan· 1 shared Vaishnavi Veerareddy· 1 shared Val J. LoweiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Karunya K. KandimallaORCID

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3 papers

Recent·Most cited

Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short-Chain Fatty Acid Butyrate

Vrishali S. Salian, Vaishnavi Veerareddy, Xiaojia Tang, Yang Xiao, Krishna R. Kalari, Purna Kashyap, Karunya K. Kandimalla

This study shows butyrate reduces Aβ42 and TNF-α-induced VCAM-1 expression in BBB endothelial cells by modulating the STAT3/GATA6 axis.

bioRxiv · Dec 17, 2025 · PreprintMolecular Biology

Elucidating Molecular Mechanisms Governing TNF-Alpha-Mediated Regulation of Amyloid Beta 42 Uptake in Blood-Brain Barrier Endothelial Cells

Vrishali S. Salian, Geoffry L. Curran, Val J. Lowe, Xiaojia Tang, Krishna R. Kalari, Karunya K. Kandimalla

This study shows TNF-alpha increases A{beta}42 accumulation in BBB endothelial cells by altering endocytosis-related proteins, linking inflammation to A{beta} pathology in Alzheimer's disease.

Molecular Pharmacology · Nov 16, 2025Peer-reviewedMolecular Biology

Clustering-based time series analysis on insulin response in the blood-brain barrier

Krishna R. Kalari, Zengtao Wang, Xiaojia Tang, Suresh Kumar Swaminathan, Karunya K. Kandimalla

The paper analyzes insulin-responsive gene expression dynamics in BBB cells to identify molecular mechanisms linking insulin resistance to AD pathology.

bioRxiv · Mar 7, 2021 · PreprintBioinformatics