Val J. Lowe

This study investigates how metabolic syndrome in mice affects amyloid-beta and glucose transport across the blood-brain barrier, linking insulin resistance to Alzheimer's disease pathology.

This study shows TNF-alpha increases A{beta}42 accumulation in BBB endothelial cells by altering endocytosis-related proteins, linking inflammation to A{beta} pathology in Alzheimer's disease.

The paper uses digital spatial profiling to analyze transcriptomic changes in the neurovascular unit of Alzheimer's transgenic mice, identifying dysregulated signaling and potential therapeutic targets.

The paper demonstrates that transplanting corrected hepatocytes into mesenteric lymph nodes cures a pig model of tyrosinemia by repopulating the diseased liver and restoring liver function.