Purna Kashyap

This study shows that an engineered probiotic expressing an endolysin reduces Clostridioides difficile infection in mice with disrupted microbiota.

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study shows butyrate reduces amyloid-beta 42 accumulation at the blood-brain barrier by activating insulin signaling pathways and improving BBB integrity.

This study shows butyrate reduces Aβ42 and TNF-α-induced VCAM-1 expression in BBB endothelial cells by modulating the STAT3/GATA6 axis.

This study shows gut microbiota affects drug absorption and metabolism by altering gene expression and intestinal permeability in mice.

The paper identifies distinct gut microbiome signatures during acute SARS-CoV-2 infection that predict long COVID, showing microbiome profiles better predict risk than clinical variables.

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.

This study uses C. elegans to screen human gut microbiota for colonization and resistance against C. difficile, finding 46% colonization success and 50% in vivo inhibition of C. difficile.

This study identifies shared and disease-specific host-microbiome interactions in colorectal cancer, inflammatory bowel disease, and irritable bowel syndrome using machine learning.