Author

Vrishali S. Salian

University of MinnesotaORCID 0000-0003-4335-9307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Karunya K. KandimallaiD· 3 shared Krishna R. KalariiD· 3 shared Val J. LoweiD· 2 shared Xiaojia TangiD· 2 shared Geoffry L. Curran· 1 shared Kevin J. ThompsoniD· 1 shared Purna KashyapiD· 1 shared Vaishnavi Veerareddy· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Karunya K. KandimallaORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintDec 17, 2025

Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short-Chain Fatty Acid Butyrate

Vrishali S. Salian, Vaishnavi Veerareddy, Xiaojia Tang…·Karunya K. Kandimalla

This study shows butyrate reduces Aβ42 and TNF-α-induced VCAM-1 expression in BBB endothelial cells by modulating the STAT3/GATA6 axis.

1 citation

humanbulk RNA-seq

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Molecular BiologyMolecular PharmacologyPeer-reviewedNov 16, 2025

Elucidating Molecular Mechanisms Governing TNF-Alpha-Mediated Regulation of Amyloid Beta 42 Uptake in Blood-Brain Barrier Endothelial Cells

Vrishali S. Salian, Geoffry L. Curran, Val J. Lowe…·Karunya K. Kandimalla

This study shows TNF-alpha increases A{beta}42 accumulation in BBB endothelial cells by altering endocytosis-related proteins, linking inflammation to A{beta} pathology in Alzheimer's disease.

4 citations

mouseexperimental assay

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BioinformaticsbioRxivPreprintMar 3, 2025

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profiling

Vrishali S. Salian, Kevin J. Thompson, Xiaojia Tang…·Karunya K. Kandimalla

The paper uses digital spatial profiling to analyze transcriptomic changes in the neurovascular unit of Alzheimer's transgenic mice, identifying dysregulated signaling and potential therapeutic targets.

DOI 10.1101/2025.03.03.640886

mousespatial transcriptomics

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