Author

X. Edward Zhou

Van Andel InstituteORCID 0000-0002-1997-0483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Evan J. WordeniD· 2 shared Minmin LiuiD· 2 shared Peter A. JonesiD· 2 shared Gan‐Qiang LaiiD· 1 shared Michelle L. Dykstra· 1 shared Stacey L. ThomasiD· 1 shared Ting-Hai XuiD· 1 shared Xiaoyan Xie· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Evan J. WordenORCID

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2 papers

Recent·Most cited

Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin

Yan Yan, X. Edward Zhou, Stacey L. Thomas, Minmin Liu, Gan‐Qiang Lai, Evan J. Worden, Peter A. Jones, Ting-Hai Xu

This study reveals the molecular mechanism of DNMT3A-3L-mediated de novo DNA methylation through structural analysis of its chromatin interactions and regulatory dynamics.

Nature Structural & Molecular Biology · Oct 31, 2025Peer-reviewedMolecular Biology

The structural basis for de novo DNA methylation in chromatin

Xiaoyan Xie, Minmin Liu, X. Edward Zhou, Michelle L. Dykstra, Peter A. Jones, Evan J. Worden

This study reports Cryo-EM structures of DNMT3A2/3B3 bound to di-nucleosomes, revealing how linker length and H3K36 methylation influence DNA methylation.

bioRxiv · Dec 19, 2024 · PreprintBiophysics