Peter A. Jones

The paper analyzes bone marrow microenvironment changes in HMA-resistant MDS patients treated with guadecitabine and atezolizumab, finding that long-term survivors show reduced immunosuppressive monocytes and expanded effector lymphocytes.

This study reveals the molecular mechanism of DNMT3A-3L-mediated de novo DNA methylation through structural analysis of its chromatin interactions and regulatory dynamics.

This study reports Cryo-EM structures of DNMT3A2/3B3 bound to di-nucleosomes, revealing how linker length and H3K36 methylation influence DNA methylation.

This study shows UHRF1 ubiquitin ligase activity and DNMT1 ubiquitin reading activity are essential for maintaining low-density CpG methylation, and their disruption leads to hypomethylation and PMD formation in cancer.

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.