Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinoma
Georg Stockmaier, Suraj R. Varkhande, Peter William Krenn, Hieu-Hoa Dang, Anshu Kumar Sharma, Dominik P. Elmer, Markus J. Steiner, Nadja Zaborsky, Daniel Neureiter, Richard Greil, Jutta Horejs‐Hoeck, Nikolaus Fortelny, Iris Karina Gratz, Fritz Aberger
This study shows that HH/GLI and Hippo/YAP pathway interactions suppress T cell chemotaxis and promote immunosuppression in BCC by downregulating chemokine signaling.
bioRxiv · Jul 7, 2024 · PreprintCancer Biology