Luis A. Chiriboga

This study shows that HBV BCP mutations enhance viral replication and alter hepatocyte transcription, linking to specific HCC subtypes.

This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.

This study develops an immunocompetent mouse model of virus-induced liver fibrosis and hepatocellular carcinoma using Norway rat hepacivirus.

This study characterizes myeloid sarcoma through multi-omic profiling, identifies RAS pathway activation as a hallmark, and shows RAS inhibition reduces tumor burden in mouse models.

This study identifies genotype-specific immune and metabolic vulnerabilities in lung adenocarcinoma through cross-species analysis of human and mouse tumors.

This study uses deep learning to predict YAP1/TEAD activity from histology slides, linking histological patterns to disease aggressiveness in cancer patients.

This study identifies inflammation in tumor-adjacent lung tissue as a predictor of clinical outcome in lung adenocarcinoma using multi-omic analysis of 143 stage I cases.