Characterization of tumor heterogeneity through segmentation-free representation learning
Jimin Tan, Hortense Le, Jiehui Deng, Yingzhuo Liu, Yuan Hao, Michelle Hollenberg, Wenke Liu, Joshua M. Wang, Bo Xia, Sitharam Ramaswami, Valeria Mezzano, Cynthia A. Loomis, Nina Murrell, Andre Luis Moreira, Kyunghyun Cho, , David Fenyö
The paper introduces a segmentation-free vision transformer, CANVAS, to discover and characterize tumor microenvironment signatures from high-dimensional multiplexed images, identifying a monocytic signature linked to poor prognosis.
Nature Biomedical Engineering · Feb 20, 2025Peer-reviewedCancer Biology