Hua Zhou

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma

This study identifies inflammation in tumor-adjacent lung tissue as a predictor of clinical outcome in lung adenocarcinoma using multi-omic analysis of 143 stage I cases.

iCellR: Combined Coverage Correction and Principal Component Alignment for Batch Alignment in Single-Cell Sequencing Analysis

The paper introduces two batch alignment methods for single-cell RNA sequencing to address drop-out issues and improve clustering accuracy across batches.