GC content shapes mRNA decay and storage in human cells
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal-Cruchez, Yi Zhou, Marianne Bénard, Marie‐Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult‐Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, , Dominique Barbieri-Weill
This study shows GC content influences mRNA decay, storage, and translation in human cells, with AU-rich mRNAs regulated at the translation level and GC-rich mRNAs at the decay level.
eLife · Dec 19, 2019Peer-reviewedMolecular Biology