Antonin Morillon

Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

This study shows that the p53Y217C mutation causes inflammation, leading to oncogenic effects in male mice and teratogenic effects in female mice, with anti-inflammatory treatment improving female survival.

Translation is a key determinant controlling the fate of cytoplasmic long non-coding RNAs

The paper shows that cytoplasmic lncRNAs in yeast are translated, affecting their abundance and post-transcriptional regulation through mechanisms involving NMD and ribosome binding.

The INO80 ATP-dependent chromatin remodelling complex alleviates stalled Polymerase II to promote non-coding RNA transcription termination.

This study shows the INO80 complex helps RNA Polymerase II move past stalled positions, aiding non-coding RNA termination in yeast.

GC content shapes mRNA decay and storage in human cells

This study shows GC content influences mRNA decay, storage, and translation in human cells, with AU-rich mRNAs regulated at the translation level and GC-rich mRNAs at the decay level.

Blind exploration of the unreferenced transcriptome reveals novel RNAs for prostate cancer diagnosis

The paper introduces a reference-free computational method to identify novel RNAs for prostate cancer diagnosis, finding that 9 unannotated lncRNAs outperform existing biomarkers.

Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome

The paper shows that Dicer processes antisense lncRNAs into small RNAs in RNAi-capable yeast, with implications for the evolution of antisense transcriptomes.

Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions

The paper shows that H3K79 methylation blocks Sir3 spreading in yeast, revealing discrete subtelomeric domains defined by chromatin transitions.

Transcription-dependent spreading of canonical yeast GATA factor across the body of highly expressed genes

The paper identifies Dal80 GATA factor binding sites in yeast using ChIP-Seq and shows its association with gene bodies and high expression levels.

Bases of antisense lncRNA-associated regulation of gene expression in fission yeast

This paper investigates how antisense long non-coding RNAs (asXUTs) regulate gene expression in fission yeast by stabilizing Exo2-sensitive asXUTs, leading to transcriptional attenuation of paired-sense genes.

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin

The paper shows that HDAC-dependent histone deacetylation is critical for transcriptional silencing of facultative heterochromatin in fission yeast.