Christophe Antoniewski

A unique malignant cell type per patient tumor is encoded in each cancer cell transcriptome.

The paper identifies tumor-specific malignant cell types encoded across the transcriptome, independent of patient origin or computational biases.

Regulation of FGF/MAPK signaling at the primary cilium base controls the proliferation-neurogenesis balance in human cerebellar organoids

This study shows that ciliary dysfunction in human cerebellar organoids leads to overactivation of FGF/MAPK signaling, impairing neurogenesis and increasing progenitor proliferation.

A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification

This study compares the role of RPGRIP1L in human and mouse neural progenitor fate specification, finding distinct effects on motoneuron identity and SHH signaling.

Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis

The paper identifies an immature neuroblast population with plasticity and molecular switches in splicing regulators during neurogenesis.

Transcriptomic analysis of meiotic genes during the mitosis-to-meiosis transition in Drosophila females

The paper identifies meiotic genes expressed during mitosis in Drosophila females and shows that some are translated but not functionally active in mitotic cells.

Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature

The paper introduces a two-phase model of ageing using Smurfness to distinguish chronological age effects from biological age effects in transcriptional data.

tRNA fragments (tRFs) populations analysis in mutants affecting tRNAs processing and tRNA methylation

The paper develops a bioinformatic pipeline to analyze tRNA fragments (tRFs) in Drosophila mutants, revealing how defects in tRNA biogenesis affect tRF and snoRNA populations.

A Single-cell RNA-seq Training and Analysis Suite using the Galaxy Framework

The paper introduces a Galaxy-based suite for scRNA-seq analysis, offering workflows, training resources, and tools for preprocessing, normalization, and clustering across 10x and alternative platforms.

tRNA 2-O-methylation modulates small RNA silencing and life span in Drosophila.

This study identifies two tRNA methyltransferases in Drosophila that modulate small RNA silencing and lifespan by modifying specific tRNAs.

GC content shapes mRNA decay and storage in human cells

This study shows GC content influences mRNA decay, storage, and translation in human cells, with AU-rich mRNAs regulated at the translation level and GC-rich mRNAs at the decay level.

Dual-layer transposon repression in heads of Drosophila melanogaster

The paper investigates piRNA pathway activity in Drosophila adult tissues and identifies a dual-layer mechanism for transposon repression involving Piwi and Dicer-2.

Metavisitor, a suite of Galaxy tools for simple and rapid detection and discovery of viruses in deep sequence data

Metavisitor provides Galaxy tools for detecting and reconstructing viral genomes from deep sequence data, enabling rapid and accessible virus discovery.