Cancer BiologybioRxivPreprint
Interplay between BET Proteins and the Pre-Replication Complex Unveils Therapeutic Vulnerabilities in Cancer
Kai Doberstein, Vivica Messner, Sebastian Berlit…·Frederik Marmé
The paper investigates the interaction between BET proteins and the pre-replication complex in cancer cells, showing that combining BET and CDC7 inhibitors enhances therapeutic effects through DNA damage and genomic instability.
DOI 10.1101/2025.03.27.645172