Author

Ruzhica Bogeska

German Cancer Research CenterORCID 0000-0002-2064-1695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:whole-genome sequencing· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrian Baez‐OrtegaiD· 2 shared Alex CaganiD· 2 shared Iñigo MartincorenaiD· 2 shared Megan Druce· 2 shared Michael D. MilsomiD· 2 shared Ana‐Matea MikeciniD· 1 shared Andrew R. J. LawsoniD· 1 shared Benedikt BrorsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Adrian Baez‐OrtegaORCID

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2 papers

Recent·Most cited

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

Foteini Fotopoulou, Megan Druce, Ruzhica Bogeska, Charles David Imbusch, Viktoria Flore, Melanie Ball, Julia Knoch, Susanne Lux, Esther Rodriguez-Correa, Kleo Aurich, Ian Ghezzi, Marleen Büchler-Schäff, Ana‐Matea Mikecin, Jeyan Jayarajan, Daniel B. Lipka, , Michael D. Milsom

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

bioRxiv · May 13, 2026 · PreprintCell Biology

Somatic mutation rates scale with lifespan across mammals

Alex Cagan, Adrian Baez‐Ortega, Natalia Brzozowska, Federico Abascal, Tim H. H. Coorens, Mathijs Arnoud Sanders, Andrew R. J. Lawson, Luke M. R. Harvey, Shriram G. Bhosle, David Jones, Raul E. Alcantara, Timothy M. Butler, Yvette E. Hooks, Kirsty Roberts, Elizabeth Anderson, , Iñigo Martincorena

This study finds that somatic mutation rates per year decrease with species lifespan across mammals, suggesting evolutionary constraints on mutagenesis and its role in ageing.

Nature · Apr 13, 2022Peer-reviewedGenomics