Michael D. Milsom

WNT-driven immune evasion promotes malignant transformation of BRAF-mutant colorectal cancer

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

Dynamic DNA methylation reveals novel cis-regulatory elements in murine hematopoiesis

The paper develops a computational framework for analyzing DNA methylation data in mouse hematopoiesis, identifying novel cis-regulatory elements associated with gene expression during differentiation.

Somatic mutation rates scale with lifespan across mammals

This study finds that somatic mutation rates per year decrease with species lifespan across mammals, suggesting evolutionary constraints on mutagenesis and its role in ageing.