Author

Megan Druce

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Michael D. MilsomiD· 3 shared Adrian Baez‐OrtegaiD· 2 shared Alex CaganiD· 2 shared Esther Rodriguez-CorreaiD· 2 shared Foteini FotopoulouiD· 2 shared Ian GhezziiD· 2 shared Iñigo MartincorenaiD· 2 shared Jeyan Jayarajan· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Michael D. MilsomORCID

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3 papers

Recent·Most cited

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtěch Kumpošt, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, , Michael D. Milsom

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

Nature Cell Biology · May 25, 2026Peer-reviewedCell Biology

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

Foteini Fotopoulou, Megan Druce, Ruzhica Bogeska, Charles David Imbusch, Viktoria Flore, Melanie Ball, Julia Knoch, Susanne Lux, Esther Rodriguez-Correa, Kleo Aurich, Ian Ghezzi, Marleen Büchler-Schäff, Ana‐Matea Mikecin, Jeyan Jayarajan, Daniel B. Lipka, , Michael D. Milsom

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

bioRxiv · May 13, 2026 · PreprintCell Biology

Somatic mutation rates scale with lifespan across mammals

Alex Cagan, Adrian Baez‐Ortega, Natalia Brzozowska, Federico Abascal, Tim H. H. Coorens, Mathijs Arnoud Sanders, Andrew R. J. Lawson, Luke M. R. Harvey, Shriram G. Bhosle, David Jones, Raul E. Alcantara, Timothy M. Butler, Yvette E. Hooks, Kirsty Roberts, Elizabeth Anderson, , Iñigo Martincorena

This study finds that somatic mutation rates per year decrease with species lifespan across mammals, suggesting evolutionary constraints on mutagenesis and its role in ageing.

Nature · Apr 13, 2022Peer-reviewedGenomics