Author

Ian Ghezzi

German Cancer Research CenterORCID 0000-0002-7758-9656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Michael D. MilsomiD· 4 shared Esther Rodriguez-CorreaiD· 2 shared Foteini FotopoulouiD· 2 shared Jeyan Jayarajan· 2 shared Julia Knoch· 2 shared Kleo Aurich· 2 shared Marleen Büchler-Schäff· 2 shared Megan Druce· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Michael D. MilsomORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

WNT-driven immune evasion promotes malignant transformation of BRAF-mutant colorectal cancer

Manuel Mastel, Aitana Guiseris Martinez, Umberto Pozza, Jasmin Meier, Ioannis Chiotakakos, Sandra Jaun, Carolin Artmann, Gabriele Diamante, Nikolaos Georgakopoulos, Philipp Albrecht, Yvonne Petersen, Saskia Reuter, Barbara Schmitt, Michael Günther, Alexandra Thiran, , René Jackstadt

This study shows that WNT signaling enables immune evasion in BRAF-mutant colorectal cancer, promoting tumor progression through changes in T cell phenotypes.

Gastroenterology · Aug 1, 2026Peer-reviewedCancer Biology

A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells

Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtěch Kumpošt, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, , Michael D. Milsom

This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.

Nature Cell Biology · May 25, 2026Peer-reviewedCell Biology

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

Foteini Fotopoulou, Megan Druce, Ruzhica Bogeska, Charles David Imbusch, Viktoria Flore, Melanie Ball, Julia Knoch, Susanne Lux, Esther Rodriguez-Correa, Kleo Aurich, Ian Ghezzi, Marleen Büchler-Schäff, Ana‐Matea Mikecin, Jeyan Jayarajan, Daniel B. Lipka, , Michael D. Milsom

This study shows that HSC dormancy, not apoptosis, limits mutagenesis in aging, with dormancy disruption accelerating mutation rates.

bioRxiv · May 13, 2026 · PreprintCell Biology

Oncodevelopmental plasticity of the skeleton in myeloid neoplasms

Salim Atakhanov, Ian Ghezzi, Hector Tejeda Mora, Lucas Greven, Marta Rizk, Lina Schmidt, Katrin Goetz, Lina Merg, Valeria Solozobova, Adam Benabid, Pia Wanner, Niklas Lutterbach, Aleksandar V. Kargaliev, Mathias Schäfersküpper, Alexandru Florea, , Rebekka K. Schneider

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

bioRxiv · Mar 21, 2026 · PreprintCancer Biology