A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Esther Rodriguez-Correa, Florian Grünschläger, Tamar Nizharadze, Natasha Anstee, Jude Al-Sabah, Vojtěch Kumpošt, Anastasia Sedlmeier, Congxin Li, Melanie Ball, Foteini Fotopoulou, Jeyan Jayarajan, Ian Ghezzi, Julia Knoch, Megan Druce, Kleo Aurich, , Michael D. Milsom
This study uses single-cell transplantation and mathematical modeling to show that lineage biases in hematopoiesis arise from extrinsic feedback and clonal competition, not intrinsic HSC properties.
Nature Cell Biology · May 25, 2026Peer-reviewedCell Biology