Zander Harteveld

This paper introduces nCycle-Forge, a computational method for designing cyclic peptides that outperforms existing approaches in hit rate and potency against two targets.

This study designs polymorph-specific binders for α-synuclein fibrils using a computational pipeline, demonstrating their utility as selective labeling agents without interfering with fibril dynamics.

This paper introduces a deep learning framework called Genesis to learn protein structural patterns and demonstrates its ability to design novel protein folds with high protease resistance.

This paper introduces a framework for de novo protein design that automatically generates structural templates and evaluates their stability through experimental characterization.

This paper introduces an optogenetic tool to control NmeCas9 activity using a light-switchable anti-CRISPR protein, enabling precise genome editing in mammalian cells.

The paper designs improved anti-CRISPR proteins with enhanced inhibition potency and expanded specificity through structure-based engineering.

rstoolbox provides tools for analyzing protein design ensembles, enabling efficient processing of decoy sets and benchmarking of design protocols.