Mareike Daniela Hoffmann

This paper reports engineered AAV capsids that directly package proteins, demonstrating efficient delivery and activity of packaged proteins.

This study shows that swapping nanobodies at specific AAV capsid hotspots enables precise tropism switching for targeted gene therapy without extensive optimization.

This paper introduces an optogenetic tool to control NmeCas9 activity using a light-switchable anti-CRISPR protein, enabling precise genome editing in mammalian cells.

The paper designs improved anti-CRISPR proteins with enhanced inhibition potency and expanded specificity through structure-based engineering.

This paper develops a cell-specific CRISPR/Cas9 activation system using miRNA-regulated anti-CRISPR proteins, demonstrating targeted gene activation in liver and muscle cells.