BioengineeringbioRxivPreprint
Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate
Jiaoyang Liao, Hongling Zhang, Shuanghong Chen…·Yuming Lu
This paper develops hpABE5.20, a base editor with improved precision and reduced off-target effects through sequential amino acid mutagenesis and AI-based structural prediction.