Author

Changrui Feng

ORCID 0000-0003-2024-8575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Da Xie· 2 shared Wendan ReniD· 2 shared Yuxuan WuiD· 2 shared Bin FuiD· 1 shared Chong-Ping Lai· 1 shared Dan LiangiD· 1 shared Dawei WangiD· 1 shared Erwei ZuoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Da Xie

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedAug 12, 2025

In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery

Saijuan Xu, Dan Liang, Qiudao Wang…·Yuxuan Wu

This paper develops an antibody-free lipid nanoparticle system for in vivo mRNA delivery to human HSCs, enabling efficient base editing of HBG to treat blood disorders like beta-thalassemia and sickle cell disease.

29 citationstop 1%

humanexperimental assay

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BioengineeringbioRxivPreprintMay 14, 2025

Sequential Amino Acid Mutagenesis-Driven De Novo Evolution of Adenine Deaminases Enables Efficient In Vivo Base Editing in Primate

Jiaoyang Liao, Hongling Zhang, Shuanghong Chen…·Yuming Lu

This paper develops hpABE5.20, a base editor with improved precision and reduced off-target effects through sequential amino acid mutagenesis and AI-based structural prediction.

3 citations

non-human primateDNA methylation

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