Zaher Elbeck

This study identifies miR-208b-3p as a regulator linking cardiac stress adaptation with redox and survival responses through its effects on Myh7 and ATM.

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.