Thomas J. LaRocca

Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans

This study shows apigenin extends healthspan and protects against Alzheimer's proteotoxicity in C. elegans by reducing oxidative stress and improving physiological function.

Mitochondrial double-stranded RNA accumulation in brain aging and Alzheimer's disease

This study identifies mitochondrial double-stranded RNA (mt-dsRNA) accumulation as a driver of chronic inflammation in brain aging and Alzheimer's disease, correlating with cognitive decline and genetic risk factors.

Predicting cell type-specific extracellular vesicle biology using an organism-wide single cell transcriptomic atlas - insights from the Tabula Muris

The paper uses a single-cell transcriptomic atlas to predict cell type-specific extracellular vesicle biology, identifying gene expression patterns and networks associated with EV secretion.

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimers Disease (AD) Human Organoid and Mouse Models

This paper demonstrates that NI112, a brain-penetrant Nanoligomer targeting NF-κB and NLRP3, improves functional outcomes and reduces neuroinflammation in ALS and AD human organoid and mouse models.

Amyloid beta acts synergistically as a pro-inflammatory cytokine

This study shows that amyloid beta acts as a pro-inflammatory cytokine by synergizing with other cytokines to activate astrocytes in a manner distinct from high-dose effects.

Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood

The paper applies a bioinformatic pipeline to RNA-seq data from ALS patients and controls to identify novel virus-like sequences.

Healthy aging interventions reduce non-coding repetitive element transcripts

The paper investigates how healthy aging interventions affect non-coding repetitive element transcripts in mice and humans, finding they are globally reduced by interventions and increased by aging.