Author

Alistair B Lawrence

Roslin InstituteORCID 0000-0002-2083-4243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:plant (other)· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Sarah M. BrowniD· 2 shared Barbara Bo-Ju ShihiD· 1 shared Barry W. McColliD· 1 shared David Arthur HumeiD· 1 shared Gerard ThompsoniD· 1 shared Jack BarringtoniD· 1 shared Josef PrilleriD· 1 shared KIM M. SUMMERSiD· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Sarah M. BrownORCID

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2 papers

Recent·Most cited

Defining the pig microglial transcriptome reveals their core signature, regional heterogeneity, and similarity with humans

Barbara Bo-Ju Shih, Sarah M. Brown, Jack Barrington, Lucas Lefèvre, Neil Andrew Mabbott, Josef Priller, Gerard Thompson, Alistair B Lawrence, Barry W. McColl

The paper defines the pig microglial transcriptome, identifies a core signature of 365 genes, reveals regional heterogeneity, and shows greater similarity between pig and human microglia than pig and mouse.

Glia · Sep 19, 2022Peer-reviewedBioinformatics

Environmentally enriched pigs have transcriptional profiles consistent with neuroprotective effects and reduced microglial activity

Sarah M. Brown, Stephen J. Bush, KIM M. SUMMERS, David Arthur Hume, Alistair B Lawrence

This study shows that environmental enrichment in pigs increases neuronal activity and synaptic plasticity genes while reducing microglial activity, similar to findings in rodents.

Behavioural Brain Research · May 17, 2018Peer-reviewedMolecular Biology