Author

Lucas Lefèvre

UK Dementia Research InstituteORCID 0000-0003-0925-7411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Barry W. McColliD· 3 shared Jack BarringtoniD· 3 shared Stefan SzymkowiakiD· 2 shared Alan L. ArchibaldiD· 1 shared Alessio AlfieriiD· 1 shared Alice Drake· 1 shared Alistair B LawrenceiD· 1 shared Anirudh PatiriD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Barry W. McCollORCID

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4 papers

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMay 1, 2024

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

Anirudh Patir, Jack Barrington, Stefan Szymkowiak…·Barry W. McColl

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

19 citations

mousebulk RNA-seq

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NeuroscienceeLifePeer-reviewedNov 6, 2023

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's Disease

Michael J. D. Daniels, Lucas Lefèvre, Stefan Szymkowiak…·Barry W. McColl

This study investigates the sex-specific role of Cst7 in microglia in an amyloid-driven Alzheimer's Disease model, finding sexually dimorphic effects on endolysosomal function and inflammation.

30 citations

mousebulk RNA-seq

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BioinformaticsGliaPeer-reviewedSep 19, 2022

Defining the pig microglial transcriptome reveals their core signature, regional heterogeneity, and similarity with humans

Barbara Bo-Ju Shih, Sarah M. Brown, Jack Barrington…·Barry W. McColl

The paper defines the pig microglial transcriptome, identifies a core signature of 365 genes, reveals regional heterogeneity, and shows greater similarity between pig and human microglia than pig and mouse.

15 citations

plant (other)bulk RNA-seq

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GenomicsPLoS GeneticsPeer-reviewedSep 15, 2017

A High Resolution Atlas Of Gene Expression In The Domestic Sheep (Ovis aries)

Emily L. Clark, Stephen J. Bush, Mary E. B. McCulloch…·David Arthur Hume

This paper presents a high-resolution gene expression atlas for sheep, identifying transcriptional signatures and functional annotations across tissues and developmental stages.

175 citationstop 1%

bulk RNA-seqstatistical model

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