Josef Priller

This paper introduces an automated method to quantify white matter hyperintensity confluence, showing it correlates with cognitive performance and dementia subtypes beyond volume.

The paper examines how disrupted forward connectivity in the parieto-temporal network relates to memory impairment and AD pathology using fMRI and DCM in a longitudinal study.

This study examines how episodic memory network dysfunction relates to AD biomarkers, neurodegeneration, and cognition using longitudinal fMRI data from the DZNE study.

This study shows that lateral ventricle volume oscillations drive CSF flow and clearance, influenced by cortical blood-volume changes and physiological drivers.

The paper demonstrates that 40 Hz SSVEPs can be reliably measured during frequency-matched electrical brain stimulation, distinguishing neuronal activity from electrical artefacts.

The paper introduces cyCONDOR, a computational framework for high-dimensional cytometry data analysis, offering scalable and user-friendly tools for preprocessing, clustering, and downstream biological interpretation.

The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

This study uses snRNAseq to analyze glial cell heterogeneity in Huntington's disease across brain regions, identifying subtype-specific changes and potential mechanisms of glial dysfunction.

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

This study shows that FMRP loss in microglia increases RAC1 signaling, leading to inflammation and neuronal hyperexcitability in FXS, which can be mitigated by RAC1 inhibition.

The paper examines circadian gene expression in microglia across health and Huntington's disease, finding disrupted rhythms in symptomatic mice.

This study shows that microglia are not essential for synaptic pruning during development but influence hippocampal network function in adult mice.

The paper examines if fractional anisotropy of the fornix mediates the link between Mediterranean diet adherence and verbal memory decline in older adults over four years.

The paper identifies diagnostic images that correlate with Alzheimer's biomarkers and show differential neural processing in MCI patients compared to healthy controls.

This study shows that C9orf72 mutations disrupt autophagy in microglia, leading to immune dysfunction and increased motor neuron death in ALS/FTD.

The paper defines the pig microglial transcriptome, identifies a core signature of 365 genes, reveals regional heterogeneity, and shows greater similarity between pig and human microglia than pig and mouse.

This study finds that lifelong musical activity is linked to better cognitive abilities and preserved brain structure in older adults, suggesting it may enhance cognitive resilience.

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

The paper analyzes the transcriptome of human microglia across brain regions, aging, and disease to identify genetic effects on gene expression and splicing, linking them to neurological disorders.

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.

The paper assesses memorability of photographs in healthy controls, subjective cognitive decline, and mild cognitive impairment, identifying images with diagnostic potential.