Stanley C. Winistorfer

The paper develops insulated vectors for transgene expression in eHAP cells, enabling efficient transfection and expression, and demonstrates their use in generating transgenic heterozygous diploid cells.

The paper shows that K48- and K63-linked polyubiquitination of post-ER proteins leads to distinct degradation pathways via different proteases.

This study identifies the molecular interaction between PMP22 and MPZ through their transmembrane domains and shows how disrupting this interaction causes a loss-of-function phenotype in hereditary neuropathy.