PMP22 associates with MPZ via their transmembrane domains and disrupting this interaction causes a loss-of-function phenotype similar to hereditary neuropathy associated with liability to pressure palsies (HNPP).
Natalya Pashkova, Tabitha A. Peterson, Christopher P. Ptak…·Robert C. Piper
This study identifies the molecular interaction between PMP22 and MPZ through their transmembrane domains and shows how disrupting this interaction causes a loss-of-function phenotype in hereditary neuropathy.