Edgar G. Engleman

The paper identifies that TNFα secretion by tumor-infiltrating myeloid DCs is critical for CD8 T cell cytotoxicity, and shows that DC vaccines lose this function, limiting their efficacy.

The paper constructs a pan-cancer single-cell atlas to improve tumor identity inference and identify genetic vulnerabilities by integrating high-quality malignant cells across multiple cancers.

The paper shows cancer cells redistribute mitochondria to sustain immunosuppressive ecosystems, reprogramming immune cells and enhancing their own metabolic resilience.

This paper demonstrates that rapid irradiation of blood products with ultra-high dose rates can effectively sterilize them against bacteria and viruses while preserving functional integrity.

CELESTA identifies cell types in multiplexed in situ images by integrating protein expression and spatial information, revealing novel spatial biology associated with lymph node metastasis.

This paper introduces immunoStates, a basis matrix that reduces biological and technical biases in cell-mixture deconvolution by incorporating diverse disease states and microarray platforms.