Sanket Rajan Gupte

Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells

The paper uses cryoEELS and cryoET to study calcium distribution in mitochondria of human retinal ganglion cells under calcifying conditions, revealing mitochondrial calcification.

CryoViT: Efficient Segmentation of Cryogenic Electron Tomograms with Vision Foundation Models

CryoViT improves segmentation of large subcellular structures in cryoET data using vision transformers, outperforming U-Net-based methods with limited training data.

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

This study uses cryoET and proteomics to identify mitochondrial and organelle abnormalities in HD models, showing potential for early diagnosis and therapy development.