Chun‐Wei Lin

Grb2 Phosphorylation Antagonizes EGFR-driven Ras Activation by Interfering with Condensate Assembly

This study shows that Grb2 phosphorylation at Y160 inhibits EGFR condensate formation, thereby reducing Ras activation, and reveals how kinase inhibition can promote Ras signaling under certain conditions.

An On-Demand Nanodisc Platform for Reconstitution of Functional Membrane Proteins into Model and Living Membranes

This paper develops a nanodisc platform for rapidly reconstituting functional membrane proteins into model and living membranes, demonstrating its effectiveness with calcium channels and GPCRs.

Nanodisc-Mediated Visualization of Crowding-Induced Condensation and Membrane Reorganization in Two-Dimensional Membrane Environments

The paper visualizes crowding-induced membrane condensation and reorganization using nanodiscs, showing surface-density-driven effects on lipid mobility and diffusion barriers.

Enzymatic reactions dictated by the 2D membrane environment

This study examines how the membrane environment affects enzymatic reactions, finding that it enhances activity but imposes diffusion limitations, which can be mitigated by adjusting enzyme membrane affinity.