Author

L. J. Nugent Lew

University of California, BerkeleyORCID 0000-0002-5717-5560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jay T. GrovesiD· 2 shared Joseph B. DeGrandchampiD· 2 shared Brittany L. Stinger· 1 shared Chun‐Wei LiniD· 1 shared Henry T. PhaniD· 1 shared Sameer Vikram RajeshiD· 1 shared Serena J. Huang· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

Jay T. GrovesORCID

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2 papers

Recent·Most cited

BiophysicsPLoS ONEPeer-reviewedOct 26, 2026

Grb2 Phosphorylation Antagonizes EGFR-driven Ras Activation by Interfering with Condensate Assembly

Henry T. Phan, Chun‐Wei Lin, Brittany L. Stinger…·Jay T. Groves

This study shows that Grb2 phosphorylation at Y160 inhibits EGFR condensate formation, thereby reducing Ras activation, and reveals how kinase inhibition can promote Ras signaling under certain conditions.

4 citations

experimental assaycell signaling & trafficking

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BiophysicsbioRxivPreprintJan 25, 2026

Supported membrane assay probes PLCγ1 activity in LAT condensates

Joseph B. DeGrandchamp, Sameer Vikram Rajesh, L. J. Nugent Lew, Jay T. Groves

This paper develops an image-based assay to measure PLCγ1 activity in LAT condensates and finds that condensation does not enhance PLCγ1 activity.

1 citation

imagingexperimental assay

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