Joseph B. DeGrandchamp

This study shows that Grb2 phosphorylation at Y160 inhibits EGFR condensate formation, thereby reducing Ras activation, and reveals how kinase inhibition can promote Ras signaling under certain conditions.

This study shows LAT condensation gates PLCγ1 activation through bimodal LAT phosphorylation, enhancing signal amplification and noise suppression in T cells.

This paper presents a morphology-guided deep learning platform for nanoparticle agglomeration assays, achieving high sensitivity and recall for DNA and SARS-CoV-2 RNA detection.

This paper develops an image-based assay to measure PLCγ1 activity in LAT condensates and finds that condensation does not enhance PLCγ1 activity.