The paper identifies two sEV secretion mechanisms, showing that stress activates exocytosis of multivesicular endosomes while steady-state conditions use the 'torn bag mechanism'.

Journal of Extracellular Vesicles · Aug 1, 2026Peer-reviewedCell Biology

Hybrid Tetramers of Wild-Type and Amyloidogenic H88R Transthyretin Challenge the Monomer Paradigm

Zsolt Fazekas, István L. Bódy, Helga Tar-Pálfi, Dávid Papp, Dávid Virág, Lilla Turiák, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel

This study shows that H88R transthyretin can form hybrid tetramers with wild-type chains, challenging the monomer paradigm in ATTRv.

bioRxiv · Jul 17, 2026 · PreprintMolecular Biology

Development of a Xylene-Free Sample Preparation Protocol for Quantitative Proteomics of Clinically Relevant Formaldehyde-Fixed Paraffin-Embedded Needle Biopsy Samples

Mabuse Gontse Moagi, Lívia Beke, Gábor Méhes, Gábor Kecskeméti, Zoltán Szabó, Lilla Turiák, Éva Csősz

This study develops a xylene-free proteomics protocol for FFPE needle biopsy samples, showing distinct proteomic patterns in liver conditions.

Proteomes · Jun 14, 2026Peer-reviewedMolecular Biology

A549 tumorigenic and BEAS-2B non-tumorigenic cell line derived small extracellular vesicles show distinct proteomic, N-glycoproteomic and chondroitin/dermatan sulfate profiles

Mirjam Balbisi, Tamás Langó, Virág Nikolett Horváth, Domonkos Pál, Gitta Schlosser, Gábor Kecskeméti, Zoltan Szabo, Kinga Ilyés, Nikolett T. Nagy, Otília Tóth, Jing Zheng, Guinevere S. M. Lageveen‐Kammeijer, Tamás Visnovitz, Zoltán Varga, Beáta G. Vértessy, Lilla Turiák

This study compares proteomic, N-glycoproteomic, and chondroitin/dermatan sulfate profiles of small EVs from A549 and BEAS-2B cell lines, revealing distinct molecular features associated with tumorigenicity.

Molecular & Cellular Proteomics · Feb 4, 2026Peer-reviewedCancer Biology