Ádám Dénes

The paper identifies two sEV secretion mechanisms, showing that stress activates exocytosis of multivesicular endosomes while steady-state conditions use the 'torn bag mechanism'.

This paper characterizes [3H]AZ12464237 as a high-affinity radioligand for the P2Y12 receptor, showing selectivity and utility in in vitro studies.

The paper examines the association between objective sleep efficiency and hippocampal subfield volumes in older adults, finding a positive link with entorhinal cortex volume and better memory performance.

The paper identifies a 'torn bag mechanism' for small extracellular vesicle release through membrane rupture of amphisomes, showing that both ILVs and small EVs originate from different pathways.

This study investigates the role of microglial-derived IL-1 in experimental ischemic stroke, finding it does not affect acute damage but influences neurorepair and functional recovery.

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

This study identifies microglia as key regulators of cerebral blood flow and neurovascular coupling through P2Y12R-mediated mechanisms in mice and humans.

This study identifies somatic purinergic junctions between microglia and developing neurons across developmental stages, suggesting they facilitate communication and regulation of neurogenesis.

This study investigates the role of P2Y12R in Parkinson's disease progression in mice, showing that its inhibition can protect against neurodegeneration and neuroinflammation.

This study shows that microglial NKCC1 regulates ion homeostasis, inflammation, and brain injury through cell-autonomous mechanisms.

The paper identifies specialized somatic microglia-neuron junctions that enable microglia to monitor and protect neuronal function through purinergic signaling.

The paper reveals that hippocampal cholinergic terminals form synapses and co-transmit GABA and acetylcholine via distinct vesicles, influencing hippocampal activity and potential therapeutic strategies.

The paper shows that mitochondrial ultrastructure in axons correlates with synaptic performance in mice and humans, indicating activity-dependent plasticity of mitochondria in response to synaptic demand.