EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA
Guilherme Piovezani Ramos, Daniel Zeve, Amy Shepherd, Elisa Saint‐Denis, Olivia Aldefer, Bianca Frintu, Stanley Dale, Karina Sharma, Emma Mohlmann, Prabhath Mannam, Morgan Byers, Jack Terzian, Claudio Henrique T. Ribeiro, Luiz Fernando Silva Oliveira, Kleiton Silva Borges, , David T. Breault
This study identifies EGFR inhibitors as inducers of enteroendocrine cell differentiation, linking their use to treatment-associated diarrhea through STAT1 signaling activation.
bioRxiv · Jun 5, 2026 · PreprintCell Biology