Author

Tong Da

University of PennsylvaniaORCID 0000-0002-2145-5843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:multiome· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Ali NajiiD· 2 shared Chengyang LiuiD· 2 shared Deeksha Lahori· 2 shared Elisabetta ManduchiiD· 2 shared Hélène C. DescampsiD· 2 shared Hilana El‐MekkoussiiD· 2 shared Jonathan SchugiD· 2 shared Klaus H. KaestneriD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersGenomics

Ali NajiORCID

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2 papers

Recent·Most cited

Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes

Elisabetta Manduchi, Hélène C. Descamps, Jinping Liu, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El‐Mekkoussi, Michelle Lee, Eseye Feleke, Diana Bernstein, Chengyang Liu, Ali Naji, Benjamin Glaser, Klaus H. Kaestner, Dana Avrahami

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

bioRxiv · Jul 2, 2025 · PreprintGenomics

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas

Michelle Y. Y. Lee, Omar Guessoum, Hilana El‐Mekkoussi, Mitchell Conery, Elisabetta Manduchi, Jonathan Schug, Hélène C. Descamps, Deeksha Lahori, Tong Da, Chengyang Liu, Ali Naji, Benjamin F. Voight, Mingyao Li, Klaus H. Kaestner

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

bioRxiv · Feb 14, 2025 · PreprintSystems Biology