Jonathan Schug

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

The paper identifies transitional cell states between alpha and beta cells in human islets using single-cell multiome data, suggesting potential for alpha-to-beta transdifferentiation.

This study identifies Foxl1 as a key driver of intestinal villification by regulating BMP, PDGFR, and planar cell polarity genes in telocyte progenitors.

This study uses single-cell transcriptomics and machine learning to predict T1D development in autoantibody-positive donors and identifies shared gene signatures across cell types.

The paper presents a computational workflow and interactive tool for analyzing single-cell RNA-seq data from pancreatic islets of diabetic and non-diabetic donors.

This study uses imaging mass cytometry to analyze pancreatic cells in T2D patients and controls, revealing changes in islet structure, cell composition, and immune cell infiltration.

The paper identifies miRNA epistasis in liver regeneration using a high-content in vivo screen in mice, revealing synergistic and redundant effects of miRNA interactions.

This study compares three commercial single-cell RNA-seq platforms using primary human islets to evaluate their performance in complex tissues.