Dana Avrahami

Latent plasticity of the human pancreas across development, health, and disease.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes

The paper examines age-related DNA methylation changes in beta and alpha cells using HPAP data, finding accelerated demethylation in T2D beta cells.

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

G6PC2 controls glucagon secretion by defining the setpoint for glucose in pancreatic α-cells

This study identifies G6PC2's role in regulating glucagon secretion in α-cells, showing it controls glucose setpoint and suggests G6PC2 inhibitors could improve glycemic control.

Multi-cell type deconvolution using a probabilistic model for single-molecule DNA methylation haplotypes

This paper develops a probabilistic model for cell type deconvolution using single-molecule DNA methylation haplotypes, showing improved accuracy in detecting rare cell types.